COVID-19 infection during pregnancy found to impact infant neurodevelopment – News-Medical.Net

COVID-19 infection during pregnancy found to impact infant neurodevelopment – News-Medical.Net

New research suggests that prenatal coronavirus disease 2019 (COVID-19) exposure increases the risk for neurodevelopmental disorders in the baby’s first year of life. The risk of neurodevelopmental disorders increased if COVID-19 infection occurred in the third trimester. The majority of diagnosed neurodevelopmental disorders involved motor and language problems.

Because children born to previously infected mothers during the pandemic are all under 2 years old, it is still unknown how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure affects long-term development. Longitudinal studies are needed to confirm the full extent of COVID-associated neurological effects, the results suggest pregnant people should take precautions in avoiding the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Study: Neurodevelopmental outcomes at one year in offspring of mothers who test positive for SARS-CoV-2 during pregnancy. Image Credit: Onjira Leibe/Shutterstock

The study was recently published in the medRxiv* preprint server whilst it undergoes peer review.

How they did it

The researchers collected medical records from hospitals and medical centers in Massachusetts to identify people who gave birth between March and September 2020 and who had a history of COVID-19 illness. Since SARS-CoV-2 has disproportionally affected minorities, the researchers also collected race and ethnicity data to control for other outside factors that could explain the results.

A SARS-CoV-2 diagnosis during pregnancy was confirmed with a record of a positive PCR test result. The researchers categorized the timing of exposure with a person’s trimester. Individuals without a positive PCR test were considered negative for the study.

The researchers also accounted for other extraneous factors such as maternal age, public versus private insurance, the biological sex of the child, and preterm status.

Characteristics of mother and child

In total, the researchers included 7,772 live births from 7,466 pregnancies in their analysis. The average age of the mother was 32.9 years, with 69% being Caucasian.

Of the 7,772 births, 222 mothers were infected with SARS-CoV-2 during pregnancy (2.9%).

Exposed mothers were significantly less likely to be of white or Asian race. In contrast, most infections occurred in mothers of Hispanic ethnicity. Additionally, mothers who were infected were more likely to have public insurance.

Preexisting conditions such as diabetes and hypertension were similar across exposed and unexposed mothers and exposed mothers were more likely than unexposed mothers to have a preterm delivery (14% vs. 8.7%).


Babies from exposed mothers were more likely to receive a neurodevelopmental diagnosis within the first year of life. Specifically, 6.3% of babies had a diagnosis compared to 3% of unexposed babies.

The most common neurodevelopmental diagnoses included specific developmental disorders of motor function, expressive language disorders, and developmental disorders of speech and language.

Babies born to exposed mothers tended to receive their diagnosis two months earlier than babies from unexposed mothers (214 days vs. 275 days).

The risk for neurodevelopmental disorders increased if SARS-CoV-2 infection occurred during the third trimester of pregnancy.

There was a greater risk of preterm delivery when there was a SARS-CoV-2 infection during pregnancy. However, further analyses showed a lack of association between preterm birth and neurodevelopmental diagnoses …….