‘Deadly carrot’ compound may be effective against SARS-CoV-2 – Medical News Today

‘Deadly carrot’ compound may be effective against SARS-CoV-2 – Medical News Today

Share on PinterestThe so-called deadly carrot (Thapsia garganica) in bloom. DeAgostini/Getty Images

  • A new study investigates how SARS-CoV-2 behaves when two variants of the virus coinfect human cells.
  • The researchers found that the Delta variant replicates four times faster than the Alpha variant and nine times faster than the Beta variant.
  • They also demonstrated that a recently discovered antiviral called thapsigargin successfully blocks the infection in cell cultures.

The success of the vaccination program in the fight against SARS-CoV-2, the virus that causes COVID-19, is being hampered by the virus continually mutating.

Many of the changes have little impact on the virus, but some alter how it spreads and the severity of the resulting disease. The mutations may also alter the performance of vaccines.

The World Health Organization (WHO) tracks all SARS-CoV-2 variants. The organization adds them to its list of variants of concern if they do any of the following:

  • increase the speed at which the virus can spread
  • increase the severity or change the symptoms of COVID-19
  • decrease the available treatment options or the effectiveness of measures to control the virus

The current list includes the Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), and Omicron (B.1.1.529) variants.

A recent study conducted at the University of Nottingham, in the United Kingdom, looked at the infection performance of theAlpha, Beta, and Delta variants in cell cultures.

The researchers studied the variants individually and together to understand what happens if a person contracts two variants at the same time — which is called coinfection.

The team also investigated the performance of thapsigargin, which the authors call a “recently discovered, broad-spectrum antiviral.”

The results appear in the journal Virulence.

The researchers found that the Delta variant replicated and spread between cells the quickest. It replicated four times faster than the Alpha variant and nine times faster than the Beta variant.

During coinfection, the Delta variant boosted the replication of both the Alpha and Beta variants. Replication was also quicker during coinfection with the Alpha and Delta or Alpha and Beta variants, compared with the sum of the individual replication rates.

Reports of breakthrough infections in fully vaccinated people highlight that vaccines cannot guarantee safety from a constantly changing target and that extra treatments are needed.

Antiviral drugs and similar medications can help the body fight off viruses, shorten the duration of viral infections, and reduce the symptoms of these illnesses.

According to the U.K.’s Medicines and Healthcare products Regulatory Agency, certain antivirals are safe and effective at reducing the risk of severe COVID-19 in at-risk people.

Antivirals work in different ways, depending the specific drug. The most common ways involve:

Alternative medicines