Preliminary Study Shows Promise For Long-Term Treatment Of Diabetes – Forbes

Preliminary Study Shows Promise For Long-Term Treatment Of Diabetes – Forbes

Human embryonic stem cells

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This story is part 8 of an occasional series on the current progression in Regenerative Medicine. In 1999, I defined regenerative medicine as the collection of interventions that restore to normal function tissues and organs that have been damaged by disease, injured by trauma, or worn by time. I include a full spectrum of chemical, gene, and protein-based medicines, cell-based therapies, and biomechanical interventions that achieve that goal.

Results of a preliminary study show that we may be one step closer to achieving a long-term cure for Type 1 diabetes. After decades of research, there now seems to be at least partial success at transplanting functional insulin-producing islet cells into the human pancreas.

Type 1 diabetes is a major public health crisis. The disease occurs when the body’s immune system attacks its own insulin-producing pancreatic cells. Without these insulin-producing cells, patients are at risk for blindness, disabilities, and are at increased risk for Covid-19.

Researchers from the Harvard Stem Cell Institute and Vertex Pharmaceuticals have discovered a method of growing insulin-producing pancreatic cells from stem cells. These insulin-producing cells can then be implanted into the pancreas of Type 1 diabetes patients. If the study continues to be successful, these researchers will have created a method to produce an unlimited supply of insulin-producing pancreatic cells to treat and possibly cure Type 1 diabetics.

The process of developing this method began with understanding which chemical signals were needed to steer stem cells into insulin-producing cells. Stem cells are a type of cell that can be reprogrammed into earlier, embryonic stages of development. With the right chemical signals, stem cells can then be transformed into almost any other cell in the body.

To guide stem cells into insulin-producing pancreatic cells, the research team at Harvard focused their efforts on learning about the development of the pancreas and discovering the mechanisms the pancreas uses to produce these cells in the first place.

After a painstaking and systematic effort to determine which chemical signals could transform stem cells into insulin-producing islet cells, the research team at Harvard finally seemed to hit upon the magic formula. Harvard then worked in collaboration with Vertex pharmaceuticals to conduct early phase clinical safety trials of the cells in Type 1 diabetics. These initial trials provided guidance for improvements in the methods used to produce the islet cells. After the success of these initial safety trials, the cells were ready for clinical trials.

The results of the clinical trials were recently published in the Cell Stem Cell Journal. An important caveat of stem cell-grown islet cells as a cure for Type 1 diabetes is that it is an autoimmune disease. So, for patients with Type 1 diabetes, their immune system will attack any cell that resembles pancreatic islet cells. For a successful transplant of pancreatic islet cells to occur in Type 1 diabetics, it is necessary to use immunosuppression tactics which essentially suppress the immune system’s attack on the islet cells. This was done by prescribing patients immunosuppressive medication before they were injected with the lab-grown islet cells. After this process, researchers followed the patient’s insulin levels to determine if the transplanted islet cells were producing sufficient levels of …….


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